Enhanced Detection of Magnetic Nanoparticles Using a Novel Microwave Ferromagnetic Resonance Imaging System

Objective: An aluminium faceted chamber designed for 3D microwave imaging (MWI) of the breast has been integrated into an electromagnet in order to carry out signal acquisition experiments inverse scattering-based ferromagnetic resonance (FRI) system, or magnetic contrast-enhanced MWI system. Methods: For this proof concept, equipped with four wire monopole antennas, and low-contrast oil-based targets have tested varying concentrations iron oxide nanoparticles (MNP) serve as contrast agents. The is capable sustaining a static polarizing field (PMF) greater than 0.2 Tesla (2000 Gauss) across modulate MNPs' response, effectively changing targets' permeability. Differential scattered data are then collected through application withdrawal PMF. Results: This study successfully characterized particular narrow band frequencies within asymmetric that demonstrate significant differential responses corresponding weak physically isolated from MNPs, on different sizes positions containing various MNPs. Conclusion: Similar (FMR) spectroscopy, which detection FMR phenomena best achieved at probing coinciding structural resonant frequency metallic cavity, these interest yield high level sensitivity MNP permeability changes suitable chamber. Significance: These represent first experimental results full-scale FRI system detecting eventually MNPs biologically relevant concentrations.